Laboratories

Optoacoustic Mesoscopy

Different layers of human skin obtained with RSOM.
Different layers of human skin obtained with RSOM.
a) Maximum intensity projection (MIP) in the coronal direction showing the Stratum corneum of the epidermis, b) MIP in the coronal direction showing vascular fingerprint of the dermal papillae, c) MIP in the coronal direction showing the subpapillary plexus, and d) MIP in the coronal direction showing the deep vessels of the papillary dermis. e) Cross section through human skin. (b-d) MIPs along the depth direction within the regions marked in (e).
All scale bars are 500 µm.
Figure: CBI

Our group conceives, designs and develops multispectral optoacoustic technology that allows performing non-invasive anatomical, functional and molecular optical imaging of the skin in the clinics. Our systems are designed to achieve a resolution to depth relation that is not accessible to the traditional optical imaging techniques.  As a result, high resolution capabilities across the whole skin depth are maintained. Within this framework we use our tools to image and quantify biologically and medically relevant features that were not possible to be monitored before.  Furthermore leveraging in our technology and collaborating with leading dermatologists we study several major skin disorders in order to catalyze biomedical discovery and to improve current dermatology praxis.

Relevant publications

B. Hindelang, B.; Aguirre, J.; Schwarz, M.; Berezhnoi, A.; Eyerich, K.; Ntziachristos, V.; Biedermann, T.; Darsow, U. Non‐invasive imaging in dermatology and the unique potential of Raster‐Scan Optoacoustic Mesoscopy (RSOM) Journal of the European Academy of Dermatology and Venereology 13 November 2018 Link to online version: Link to online version: https://doi.org/10.1111/jdv.15342

Aguirre, J.; Hindelang, B.; Berezhnoi, A.; Darsow, U.; Lauffer, F.; Eyerich, K.; Biedermann, B.; Ntziachristos, V. Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy Photoacoustics Volume 10, June 2018 Link to online version: https://doi.org/10.1016/j.pacs.2018.02.002

Berezhnoi, A.; Schwarz, M.; Buehler A.; Ovsepian S. V.; Aguirre, J.; Ntziachristos V. Assessing hyperthermia‐induced vasodilation in human skin in vivo using optoacoustic mesoscopy Journal of Biophotonics Volume 11, Issue 11 Nov. 2018 Link to online version: https://doi.org/10.1002/jbio.201700359

Schwarz, M.; Garzorz-Stark,N.; Eyerich,K.; Aguirre, J.; Ntziachristos, V. Motion correction in optoacoustic mesoscopy Scientific Reports Volume 7, Article number: 10386 (2017) Link to online version: https://doi.org/10.1038/s41598-017-11277-y

Aguirre, J.; Schwarz, M.; Garzorz, N.; Omar, M.; Buehler, A.; Eyerich, K.; Ntziachristos, V. Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy. Nature Biomedical Engineering 1, 0068 (2017) Link to online version: doi:10.1038/s41551-017-0068

Schwarz, M. ; Omar, M. ; Bühler, A. ; Aguirre, J. ; Ntziachristos, V. Implications of ultrasound frequency in optoacoustic mesoscopy of the skin. IEEE Trans. Med. Imaging 34, 672-677 (2015)

Aguirre, J. ; Schwarz, M. ; Soliman, D. ; Bühler, A. ; Omar, M. ; Ntziachristos, V. Broadband mesoscopic optoacoustic tomography reveals skin layers. Opt. Lett. 39, 6297-6300 (2014)