FMT-XCT

Three-dimensional rendering of bones, skin and lung based on XCT data and FMT reconstruction of a K-ras mouse with lung tumors.
Three-dimensional rendering of bones, skin and lung based on XCT data and FMT reconstruction of a K-ras mouse with lung tumors.
Figure: Nature Methods 9(6), 615–620 (2012). doi:10.1038/nmeth.2014.

Fluorescence imaging developments have also led to the development of hybrid fluorescence molecular tomography (FMT) X-ray CT (XCT) imaging (see Ale et. al., Nature Methods 2012 9(6), 615-620, 2012). These approaches are shifting the ways of detecting cellular and sub-cellular processes in animals and humans by virtually offering in vivo staining of important biomolecules that play a crucial role in disease progression or treatment. They can therefore lead to new exploratory, diagnostic and theranostic methods.